Insights into the pleiotropic roles of ZNF703 in cancer

Zinc finger proteins (ZNFs) belong to the NET/NLZ protein family. In physiological functions, ZNF703 play significant roles in embryonic development, especially nervous system. As an transcription factors with zinc domains, abnormal regulation of is associated enhanced proliferation, invasion, and metastasis as well drug resistance many tumors, although mechanisms action vary depending on specific tumor microenvironment. lacks a nuclear localization sequence despite its function requiring DNA binding. The purpose this review summarize architecture ZNF703, tumorigenesis, progression, future oncology therapeutic prospects, which have implications for understanding susceptibility progression.